Brain Iron Detected by SWI High Pass Filtered Phase Calibrated with Synchrotron X-Ray Fluorescence
Identifieur interne : 001A83 ( Main/Exploration ); précédent : 001A82; suivant : 001A84Brain Iron Detected by SWI High Pass Filtered Phase Calibrated with Synchrotron X-Ray Fluorescence
Auteurs : Karla Hopp [Canada] ; Bogdan F. Gh. Popescu [Canada] ; Richard P. E. Mccrea [Canada] ; Sheri L. Harder [États-Unis] ; Christopher A. Robinson [Canada] ; Mark E. Haacke [États-Unis] ; Ali H. Rajput [Canada] ; Alex Rajput [Canada] ; Helen Nichol [Canada]Source :
- Journal of magnetic resonance imaging : JMRI [ 1053-1807 ] ; 2010.
English descriptors
- KwdEn :
- Alzheimer Disease (pathology), Brain (pathology), Brain Injuries (pathology), Brain Mapping, Cadaver, Calibration, Formaldehyde (pharmacology), Humans, Iron (chemistry), Models, Statistical, Muscular Atrophy (pathology), Parkinson Disease (pathology), Synchrotrons, X-Ray Absorption Spectroscopy (methods).
- MESH :
- chemical , chemistry : Iron.
- chemical , pharmacology : Formaldehyde.
- methods : X-Ray Absorption Spectroscopy.
- pathology : Alzheimer Disease, Brain, Brain Injuries, Muscular Atrophy, Parkinson Disease.
- Brain Mapping, Cadaver, Calibration, Humans, Models, Statistical, Synchrotrons.
Abstract
To test the ability of susceptibility weighted images (SWI) and high pass filtered phase images to localize and quantify brain iron.
Magnetic resonance (MR) images of human cadaver brain hemispheres were collected using a gradient echo based SWI sequence at 1.5T. For X-ray fluorescence (XRF) mapping, each brain was cut to obtain slices that reasonably matched the MR images and iron was mapped at the iron K-edge at 50 or 100 μm resolution. Iron was quantified using XRF calibration foils. Phase and iron XRF were averaged within anatomic regions of one slice, chosen for its range of iron concentrations and nearly perfect anatomic correspondence. X-ray absorption spectroscopy (XAS) was used to determine if the chemical form of iron was different in regions with poorer correspondence between iron and phase.
Iron XRF maps, SWI, and high pass filtered phase data in nine brain slices from five subjects were visually very similar, particularly in high iron regions. The chemical form of iron could not explain poor matches. The correlation between the concentration of iron and phase in the cadaver brain was estimated as
The phase shift Δφ was found to vary linearly with iron concentration with the best correspondence found in regions with high iron content.
Url:
DOI: 10.1002/jmri.22201
PubMed: 20512886
PubMed Central: 3843009
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000860
- to stream Pmc, to step Curation: 000860
- to stream Pmc, to step Checkpoint: 000A64
- to stream PubMed, to step Corpus: 000D44
- to stream PubMed, to step Curation: 000D44
- to stream PubMed, to step Checkpoint: 000D44
- to stream Ncbi, to step Merge: 000C72
- to stream Ncbi, to step Curation: 000C72
- to stream Ncbi, to step Checkpoint: 000C72
- to stream Main, to step Merge: 001B94
- to stream Main, to step Curation: 001A83
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain Iron Detected by SWI High Pass Filtered Phase Calibrated with Synchrotron X-Ray Fluorescence</title><author><name sortKey="Hopp, Karla" sort="Hopp, Karla" uniqKey="Hopp K" first="Karla" last="Hopp">Karla Hopp</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Popescu, Bogdan F Gh" sort="Popescu, Bogdan F Gh" uniqKey="Popescu B" first="Bogdan F. Gh." last="Popescu">Bogdan F. Gh. Popescu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Mccrea, Richard P E" sort="Mccrea, Richard P E" uniqKey="Mccrea R" first="Richard P. E." last="Mccrea">Richard P. E. Mccrea</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Harder, Sheri L" sort="Harder, Sheri L" uniqKey="Harder S" first="Sheri L." last="Harder">Sheri L. Harder</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Loma Linda University, Loma Linda, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Loma Linda University, Loma Linda, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A." last="Robinson">Christopher A. Robinson</name><affiliation wicri:level="1"><nlm:aff id="A3">Dept. of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dept. of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Haacke, Mark E" sort="Haacke, Mark E" uniqKey="Haacke M" first="Mark E." last="Haacke">Mark E. Haacke</name><affiliation wicri:level="2"><nlm:aff id="A4">The MRI Institute for Biomedical Research, Detroit, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The MRI Institute for Biomedical Research, Detroit, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Nichol, Helen" sort="Nichol, Helen" uniqKey="Nichol H" first="Helen" last="Nichol">Helen Nichol</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20512886</idno><idno type="pmc">3843009</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843009</idno><idno type="RBID">PMC:3843009</idno><idno type="doi">10.1002/jmri.22201</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000860</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000860</idno><idno type="wicri:Area/Pmc/Curation">000860</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000860</idno><idno type="wicri:Area/Pmc/Checkpoint">000A64</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A64</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000D44</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D44</idno><idno type="wicri:Area/PubMed/Curation">000D44</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D44</idno><idno type="wicri:Area/PubMed/Checkpoint">000D44</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D44</idno><idno type="wicri:Area/Ncbi/Merge">000C72</idno><idno type="wicri:Area/Ncbi/Curation">000C72</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C72</idno><idno type="wicri:doubleKey">1053-1807:2010:Hopp K:brain:iron:detected</idno><idno type="wicri:Area/Main/Merge">001B94</idno><idno type="wicri:Area/Main/Curation">001A83</idno><idno type="wicri:Area/Main/Exploration">001A83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain Iron Detected by SWI High Pass Filtered Phase Calibrated with Synchrotron X-Ray Fluorescence</title><author><name sortKey="Hopp, Karla" sort="Hopp, Karla" uniqKey="Hopp K" first="Karla" last="Hopp">Karla Hopp</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Popescu, Bogdan F Gh" sort="Popescu, Bogdan F Gh" uniqKey="Popescu B" first="Bogdan F. Gh." last="Popescu">Bogdan F. Gh. Popescu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Mccrea, Richard P E" sort="Mccrea, Richard P E" uniqKey="Mccrea R" first="Richard P. E." last="Mccrea">Richard P. E. Mccrea</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Harder, Sheri L" sort="Harder, Sheri L" uniqKey="Harder S" first="Sheri L." last="Harder">Sheri L. Harder</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Loma Linda University, Loma Linda, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Loma Linda University, Loma Linda, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A." last="Robinson">Christopher A. Robinson</name><affiliation wicri:level="1"><nlm:aff id="A3">Dept. of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Dept. of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Haacke, Mark E" sort="Haacke, Mark E" uniqKey="Haacke M" first="Mark E." last="Haacke">Mark E. Haacke</name><affiliation wicri:level="2"><nlm:aff id="A4">The MRI Institute for Biomedical Research, Detroit, Michigan, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The MRI Institute for Biomedical Research, Detroit, Michigan</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation wicri:level="1"><nlm:aff id="A5">Division of Neurology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author><author><name sortKey="Nichol, Helen" sort="Nichol, Helen" uniqKey="Nichol H" first="Helen" last="Nichol">Helen Nichol</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy & Cell Biology, University of Saskatchewan, Saskatoon, SK</wicri:regionArea><wicri:noRegion>SK</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of magnetic resonance imaging : JMRI</title><idno type="ISSN">1053-1807</idno><idno type="eISSN">1522-2586</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (pathology)</term><term>Brain (pathology)</term><term>Brain Injuries (pathology)</term><term>Brain Mapping</term><term>Cadaver</term><term>Calibration</term><term>Formaldehyde (pharmacology)</term><term>Humans</term><term>Iron (chemistry)</term><term>Models, Statistical</term><term>Muscular Atrophy (pathology)</term><term>Parkinson Disease (pathology)</term><term>Synchrotrons</term><term>X-Ray Absorption Spectroscopy (methods)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Formaldehyde</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>X-Ray Absorption Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Brain Injuries</term><term>Muscular Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Brain Mapping</term><term>Cadaver</term><term>Calibration</term><term>Humans</term><term>Models, Statistical</term><term>Synchrotrons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To test the ability of susceptibility weighted images (SWI) and high pass filtered phase images to localize and quantify brain iron.</p></sec><sec id="S2"><title>Materials and Methods</title><p id="P2">Magnetic resonance (MR) images of human cadaver brain hemispheres were collected using a gradient echo based SWI sequence at 1.5T. For X-ray fluorescence (XRF) mapping, each brain was cut to obtain slices that reasonably matched the MR images and iron was mapped at the iron K-edge at 50 or 100 μm resolution. Iron was quantified using XRF calibration foils. Phase and iron XRF were averaged within anatomic regions of one slice, chosen for its range of iron concentrations and nearly perfect anatomic correspondence. X-ray absorption spectroscopy (XAS) was used to determine if the chemical form of iron was different in regions with poorer correspondence between iron and phase.</p></sec><sec id="S3"><title>Results</title><p id="P3">Iron XRF maps, SWI, and high pass filtered phase data in nine brain slices from five subjects were visually very similar, particularly in high iron regions. The chemical form of iron could not explain poor matches. The correlation between the concentration of iron and phase in the cadaver brain was estimated as <italic>c<sub>Fe</sub></italic> [μg/g tissue] = 850Δφ + 110.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The phase shift Δφ was found to vary linearly with iron concentration with the best correspondence found in regions with high iron content.</p></sec></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li><li>Michigan</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Hopp, Karla" sort="Hopp, Karla" uniqKey="Hopp K" first="Karla" last="Hopp">Karla Hopp</name></noRegion><name sortKey="Mccrea, Richard P E" sort="Mccrea, Richard P E" uniqKey="Mccrea R" first="Richard P. E." last="Mccrea">Richard P. E. Mccrea</name><name sortKey="Nichol, Helen" sort="Nichol, Helen" uniqKey="Nichol H" first="Helen" last="Nichol">Helen Nichol</name><name sortKey="Popescu, Bogdan F Gh" sort="Popescu, Bogdan F Gh" uniqKey="Popescu B" first="Bogdan F. Gh." last="Popescu">Bogdan F. Gh. Popescu</name><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name><name sortKey="Robinson, Christopher A" sort="Robinson, Christopher A" uniqKey="Robinson C" first="Christopher A." last="Robinson">Christopher A. Robinson</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Harder, Sheri L" sort="Harder, Sheri L" uniqKey="Harder S" first="Sheri L." last="Harder">Sheri L. Harder</name></region><name sortKey="Haacke, Mark E" sort="Haacke, Mark E" uniqKey="Haacke M" first="Mark E." last="Haacke">Mark E. Haacke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A83 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A83 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3843009
|texte= Brain Iron Detected by SWI High Pass Filtered Phase Calibrated with Synchrotron X-Ray Fluorescence
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20512886" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |